However, with the mysterious death of the director and two other doctors, Dr. Tenma-losing his social standing being one of them. Unfortunately, this choice leads to serious ramifications for Dr.

Tenma stands his ground and chooses to perform surgery on the young boy Johan Liebert instead of the town's mayor. His fellow doctors, fiancée, and the hospital director applaud his accomplishment but because of the switch, a poor immigrant worker is dead, causing Dr.

While preparing to perform surgery on someone, he gets a call from the hospital director telling him to switch patients and instead perform life-saving brain surgery on a famous performer. That is until one night, a seemingly small event changes Dr. Kenzou Tenma, an elite neurosurgeon recently engaged to his hospital director's daughter, is well on his way to ascending the hospital hierarchy.